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The NK-92 cell line is an immortalised cell line that has the characteristics of a type of immune cell found in human blood called ’natural killer’ (NK) cells. Blood NK cells and NK-92 cells recognize and attack cancer cells as well as cells that have been infected with a virus, bacteria, or fungus. [1]
NK-92 cells have also been engineered to expressed chimeric antigen receptors (CARs), in an approach similar to that used for T cells. An example of this is an NK-92 derived cell engineered with both a CD16 and an anti-PD-L1 CAR; currently in clinical development for oncology indications.
Natural killer (NK) cells are a type of lymphocyte cell involved in the innate immune system's response to viral infection and tumor transformation of host cells. [20] [7] Like T cells, NK cells have many qualities characteristic of the adaptive immune system, including the production of “memory” cells that persist following encounter with antigens and the ability to create a secondary ...
Normal body cells are not recognized and attacked by NK cells because they express intact self MHC antigens. Those MHC antigens are recognized by killer cell immunoglobulin receptors (KIR) that slow the reaction of NK cells. The NK-92 cell line does not express KIR and is developed for tumor therapy. [11] [12] [13] [14]
In cancers, a Killer Activation Receptor (KAR), located on the surface of the NK cell, binds to certain molecules which only appear on cells that are undergoing stress situations. In humans, this KAR is called NKG2D and the molecules it recognizes MICA and MICB. This binding provides a signal which induces the NK cell to kill the target cell. [9]
NK cells are a type of immune cell that are found in blood whose innate function is to kill viral infected cells, cells under stress and cancer cells. The KHYG-1 cell line was established in 1997 in the laboratory of M Yagita in the department of Clinical Immunology and Haematology, Tazuke-Kofukai Medical Research Institute, Kitano Hospital ...
356 14103 Ensembl ENSG00000117560 ENSMUSG00000000817 UniProt P48023 P41047 RefSeq (mRNA) NM_001302746 NM_000639 NM_001205243 NM_010177 RefSeq (protein) NP_000630 NP_001289675 NP_001192172 NP_034307 Location (UCSC) Chr 1: 172.66 – 172.67 Mb Chr 1: 161.61 – 161.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fas ligand (FASL or CD95L) is a type-II transmembrane protein expressed ...
In both humans and mice, genes encoding the NKG2 family are clustered – in human genome on chromosome 12, in mouse on chromosome 6. [2] They are generally expressed on NK cells and a subset of CD8 + T cells, although the expression of NKG2D was also confirmed on γδ T cells, NKT cells, and even on some subsets of CD4 + T cells or myeloid cells.