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The relative risk (RR) or risk ratio is the ratio of the probability of an outcome in an exposed group to the probability of an outcome in an unexposed group. Together with risk difference and odds ratio, relative risk measures the association between the exposure and the outcome. [1]
The relative risk reduction is 0.5 (50%), while the absolute risk reduction is 0.0001 (0.01%). The absolute risk reduction reflects the low probability of getting colon cancer in the first place, while reporting only relative risk reduction, would run into risk of readers exaggerating the effectiveness of the drug. [5]
Risk is the lack of certainty about the outcome of making a particular choice. Statistically, the level of downside risk can be calculated as the product of the probability that harm occurs (e.g., that an accident happens) multiplied by the severity of that harm (i.e., the average amount of harm or more conservatively the maximum credible amount of harm).
Similarly, attributable risk percent (ARP) is used as a synonym for the attributable risk percent among the exposed. [ 3 ] In climatology , fraction of attributable risk (FAR) is used to denote a proportion of adverse event risk attributable to the human influence on climate or other forcing factor.
Attributable fraction for the population combines both the relative risk of an incident with respect to the factor, as well as the prevalence of the factor in the population. Values of AF p close to 1 indicate that both the relative risk is high, and that the risk factor is prevalent. In such case, removal of the risk factor will greatly reduce ...
While retrospective cohort studies try to compare the risk of developing a disease to some already known exposure factors, a case-control study will try to determine the possible exposure factors after a known disease incidence. Both the relative risk and odds ratio are relevant in retrospective cohort studies, but only the odds ratio can be ...
Specific to public health policy, a determinant is a health risk that is general, abstract, related to inequalities, and difficult for an individual to control. [2] [3] [4] For example, poverty is known to be a determinant of an individual's standard of health. Risk factors may be used to identify high-risk people.
A retrospective study, on the other hand, looks backwards and examines exposures to suspected risk or protection factors in relation to an outcome that is established at the start of the study. Many valuable case–control studies, such as Lane and Claypon's 1926 investigation of risk factors for breast cancer, were retrospective investigations.