Search results
Results From The WOW.Com Content Network
Its distinct amphiphilicity allows it to bury its hydrophilic head in an aqueous bulk phase and hydrophobic part in the organic bulk phase respectively. [6] Wetting solution molecules break the intermolecular forces between each molecule in the organic phase and each water molecule in the aqueous phase by displacement. [5]
optics (slit diffraction) [6] Refractive index: n = electromagnetism, optics (speed of light in vacuum over speed of light in a material) Transmittance: T = optics, spectroscopy (the ratio of the intensities of radiation exiting through and incident on a sample)
The V D is not a physiological value; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. solubility, charge, size, etc. The unit for Volume of Distribution is typically reported in litres. As body composition changes with age, V D decreases.
When these values are exceeded, the displacement of the contact line, such as the one in Figure 3, will take place by either expansion or retraction of the droplet. [31] Figure 6 depicts the advancing and receding contact angles. The advancing contact angle is the maximum stable angle, whereas the receding contact angle is the minimum stable angle.
A dispersion is a system in which distributed particles of one material are dispersed in a continuous phase of another material. The two phases may be in the same or different states of matter.
Values for other compounds may be found in a variety of available reviews and monographs. [ 2 ] : 551ff [ 21 ] [ page needed ] [ 22 ] : 1121ff [ 23 ] [ page needed ] [ 24 ] Critical discussions of the challenges of measurement of log P and related computation of its estimated values (see below) appear in several reviews.
In chemistry, biochemistry, and pharmacology, a dissociation constant (K D) is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into its component ions.
Class III – low permeability, high solubility . Example: cimetidine; The absorption is limited by the permeation rate but the drug is solvated very fast. If the formulation does not change the permeability or gastro-intestinal duration time, then class I criteria can be applied. Class IV – low permeability, low solubility . Example: bifonazole