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Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. [ 6 ] [ 7 ] Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. [ 6 ]
Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]
Idarucizumab is a non-competitive inhibitor that forms complexes with dabigatran to counteract its anticoagulant effect within minutes of administration. [8] It binds to dabigatran that is free or bound to thrombin, as well as dabigatran's active metabolites. [9]
GLP-1 drugs used for weight loss involve all kinds of side effects—good and not-so-good—that may or may not strike the average user. (Reminder that there are many of these meds now.
Incapacitating agent is a chemical or biological agent which renders a person unable to harm themselves or others, regardless of consciousness. [1]Lethal agents are primarily intended to kill, but incapacitating agents can also kill if administered in a potent enough dose, or in certain scenarios.
People can lose on average anywhere from five to 20 percent of their weight on these drugs in one year, depending on their starting point, research has found. But, before you make it to that one ...
The primary antidote to brodifacoum poisoning is immediate administration of vitamin K 1 (dosage for humans: initially slow intravenous injections of 10–25 mg repeated at 3–6 hours until normalisation of the prothrombin time; then 10 mg orally four times daily as a "maintenance dose"). It is an extremely effective antidote, provided the ...
The U.S. State Department has issued a travel warning about dangerous counterfeit pills being sold at pharmacies in Mexico that often contain fentanyl. The travel alert posted Friday says ...