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Mucin genes encode mucin monomers that are synthesized as rod-shaped apomucin cores that are post-translationally modified by exceptionally abundant glycosylation. The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis , which may be important in maintaining mucosal barriers.
Mucin 16 is a membrane associated mucin that possesses a single transmembrane domain. [9] A unique property of MUC16 is its large size. MUC16 is more than twice as long as MUC1 and MUC4 and contains about 22,000 amino acids, making it the largest membrane-associated mucin. [10] MUC16 is composed of three different domains: [11] An N-terminal domain
17831 Ensembl ENSG00000198788 ENSMUSG00000025515 UniProt Q02817 n/a RefSeq (mRNA) NM_002457 NM_023566 RefSeq (protein) NP_002448 n/a Location (UCSC) Chr 11: 1.07 – 1.11 Mb Chr 7: 141.28 – 141.31 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. Function This gene ...
Mucin-1 (MUC-1) is a heterodimer ... -1 is a transcriptional coactivator involved in the activity and stabilization of enzymes and transcription of metabolic functions.
Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. [3] Like other mucins, MUC-4 is a high-molecular weight glycoprotein. [4]The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins.
Goblet cells are simple columnar epithelial cells, having a height of four times that of their width. The cytoplasm of goblet cells tends to be displaced toward the basal end of the cell body by the large mucin granules, which accumulate near the apical surface of the cell along the Golgi apparatus, which lies between the granules and the nucleus.
Mucus is an integral part of life for dozens of animals. A new study shows that its key building blocks evolved 15 different times across 49 mammals.
Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans. [5] [6] [7]MUC-5AC is a large gel-forming glycoprotein.In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance.