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An example of a Kaplan–Meier plot for two conditions associated with patient survival. The Kaplan–Meier estimator, [1] [2] also known as the product limit estimator, is a non-parametric statistic used to estimate the survival function from lifetime data. In medical research, it is often used to measure the fraction of patients living for a ...
Kaplan–Meier graph by treatment group in aml The null hypothesis for a log-rank test is that the groups have the same survival. The expected number of subjects surviving at each time point in each is adjusted for the number of subjects at risk in the groups at each event time.
The problem with measuring overall survival by using the Kaplan-Meier or actuarial survival methods is that the estimates include two causes of death: deaths from the disease of interest and deaths from all other causes, which includes old age, other cancers, trauma and any other possible cause of death. In general, survival analysis is ...
Paul Meier (July 24, 1924 – August 7, 2011) [1] was a statistician who promoted the use of randomized trials in medicine. [2] [3]Meier is known for introducing, with Edward L. Kaplan, the Kaplan–Meier estimator, [4] [5] a method for measuring how many patients survive a medical treatment from one duration to another, taking into account that the sampled population changes over time.
Kaplan-Meier curve illustrating overall survival based on volume of brain metastases.Elaimy et al. (2011) [6] In its simplest form, the hazard ratio can be interpreted as the chance of an event occurring in the treatment arm divided by the chance of the event occurring in the control arm, or vice versa, of a study.
Kaplan–Meier estimator [ edit ] The Dvoretzky–Kiefer–Wolfowitz inequality is obtained for the Kaplan–Meier estimator which is a right-censored data analog of the empirical distribution function
It was prominently criticized in economics by Robert LaLonde (1986), [7] who compared estimates of treatment effects from an experiment to comparable estimates produced with matching methods and showed that matching methods are biased. Rajeev Dehejia and Sadek Wahba (1999) reevaluated LaLonde's critique and showed that matching is a good ...
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