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However, some topical minoxidil side effects may develop if you use minoxidil solution or foam excessively, such as by applying it more than two times per day or using too much of it on your scalp ...
[1] [2] Minoxidil sulfate acts as a potassium channel opener, among other actions, and has vasodilating, hypotensive, and trichogenic or hypertrichotic (hair growth-promoting) effects. [1] [3] Its mechanism of action in terms of hair growth is still unknown, although multiple potential mechanisms have been implicated. [1] Minoxidil sulfate is a ...
Minoxidil doesn’t usually come with side effects, and minoxidil interactions with other medications are unlikely. But still, getting a complete picture of its safety profile might help you ...
Avoids internal side effects of oral minoxidil. Can be used with other topical hair-loss medications. May be an enjoyable part of a haircare routine. Potential side effects of topical minoxidil:
Minoxidil is a prodrug that is converted by sulfation via the sulfotransferase enzyme SULT1A1 to its active form, minoxidil sulfate. The effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via both adenosine A1 receptors and two sub-types of adenosine A2 receptors (A 2A and A 2B receptors). [26]
The SULT1A1 enzyme is expressed in outer roots sheath of hair follicles. Minoxidil, the only US FDA approved topical drug for re-growing hair in male and female pattern hair loss (androgenetic alopecia patients) is a pro-drug. Minoxidil is converted to its active form (minoxidil sulfate) by the hair sulfotransferase enzyme (SULT1A1). [6]