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However, some topical minoxidil side effects may develop if you use minoxidil solution or foam excessively, such as by applying it more than two times per day or using too much of it on your scalp ...
Minoxidil doesn’t usually come with side effects, and minoxidil interactions with other medications are unlikely. But still, getting a complete picture of its safety profile might help you ...
Minoxidil sulfate is a sulfate ester of minoxidil, not a sulfate salt of the compound. [3] However, minoxidil sulfate forms an inner salt , which makes it more hydrophobic than minoxidil. [ 3 ] This is in contrast to most sulfate esters, which are usually more hydrophilic than their non-ester forms. [ 3 ]
The risks of using high-strength minoxidil include an increased likelihood of side effects. When using it as a topical solution, side effects of minoxidil may include: Skin irritation. Itching ...
Minoxidil is a prodrug that is converted by sulfation via the sulfotransferase enzyme SULT1A1 to its active form, minoxidil sulfate. The effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via both adenosine A1 receptors and two sub-types of adenosine A2 receptors (A 2A and A 2B receptors). [26 ...
The SULT1A1 enzyme is expressed in outer roots sheath of hair follicles. Minoxidil, the only US FDA approved topical drug for re-growing hair in male and female pattern hair loss (androgenetic alopecia patients) is a pro-drug. Minoxidil is converted to its active form (minoxidil sulfate) by the hair sulfotransferase enzyme (SULT1A1). [6]