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[173] [174] In men, a study found that treatment with a relatively low dosage of 20 μg/day ethinylestradiol for 5 weeks increased circulating SHBG levels by 150% and, due to the accompanying decrease free testosterone levels, increased total circulating levels of testosterone by 50% (via reduced negative feedback by androgens on the HPG axis).
Plus, many medications bring side effects for some people, Dr. Gittens says. He suggests clinicians get a base testosterone level for men taking GLP-1s and discuss their potential effects on T levels.
One study suggests that ADT can alter the hormonal balance necessary for male sexual activity. As men age, testosterone levels decrease by about 1% a year after age 30; however, it is important to determine whether low testosterone is due to normal aging, or to a disease, such as hypogonadism. [13]
A 2017 study, for example, found that eating trans fats may lower testosterone levels in the body. Not only that, ... Medication. Some medications can lower testosterone.
As finasteride doesn’t lower your testosterone levels, it shouldn’t cause any side effects related to low testosterone like reduced drive, delayed climax, or other dysfunction problems.
[46] [111] [112] Because bicalutamide does not lower androgen levels, it may be a particularly favorable antiandrogen for transgender women who wish to help preserve sex drive, sexual function, and/or fertility, as antiandrogens that strongly suppress levels of testosterone and its metabolites, such as CPA and GnRH modulators, can greatly ...
[30] [70] [71] [72] Although spironolactone is said to be a relatively weak inhibitor of 17α-hydroxylase and 17,20-lyase, [73] [30] at least compared to more potent steroidogenesis inhibitors like ketoconazole and abiraterone acetate (which can reduce testosterone concentrations to castrate levels), this action may contribute to a significant ...
In men, danazol has been found to inhibit gonadotropin secretion and markedly decrease testosterone levels, likely due to its actions as a steroidogenesis inhibitor and antigonadotropin. [43] However, even at the highest dosage assessed (800 mg/day), spermatogenesis remained unaffected.