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  2. Oxidative phosphorylation - Wikipedia

    en.wikipedia.org/wiki/Oxidative_phosphorylation

    Oxidative phosphorylation (UK / ɒ k ˈ s ɪ d. ə. t ɪ v /, US / ˈ ɑː k. s ɪ ˌ d eɪ. t ɪ v / [1]) or electron transport-linked phosphorylation or terminal oxidation is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing chemical energy in order to produce adenosine triphosphate (ATP).

  3. Metabolic pathway - Wikipedia

    en.wikipedia.org/wiki/Metabolic_pathway

    Metabolic pathways can be targeted for clinically therapeutic uses. Within the mitochondrial metabolic network, for instance, there are various pathways that can be targeted by compounds to prevent cancer cell proliferation. [17] One such pathway is oxidative phosphorylation (OXPHOS) within the electron transport chain (ETC). Various inhibitors ...

  4. Mitochondrial matrix - Wikipedia

    en.wikipedia.org/wiki/Mitochondrial_matrix

    The citric acid cycle produces NADH and FADH2 through oxidation that will be reduced in oxidative phosphorylation to produce ATP. [ 2 ] [ 3 ] The cytosolic, intermembrane space , compartment has a higher aqueous:protein content of around 3.8 μL/mg protein relative to that occurring in mitochondrial matrix where such levels typically are near 0 ...

  5. Citric acid cycle - Wikipedia

    en.wikipedia.org/wiki/Citric_acid_cycle

    The NADH generated by the citric acid cycle is fed into the oxidative phosphorylation (electron transport) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP. In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion.

  6. Electron transport chain - Wikipedia

    en.wikipedia.org/wiki/Electron_transport_chain

    Coupling with oxidative phosphorylation is a key step for ATP production. However, in specific cases, uncoupling the two processes may be biologically useful. The uncoupling protein, thermogenin —present in the inner mitochondrial membrane of brown adipose tissue —provides for an alternative flow of protons back to the inner mitochondrial ...

  7. ATP synthase - Wikipedia

    en.wikipedia.org/wiki/ATP_synthase

    The overall process of creating energy in this fashion is termed oxidative phosphorylation. The same process takes place in the mitochondria, where ATP synthase is located in the inner mitochondrial membrane and the F 1-part projects into the mitochondrial matrix. By pumping proton cations into the matrix, the ATP-synthase converts ADP into ATP.

  8. Cellular respiration - Wikipedia

    en.wikipedia.org/wiki/Cellular_respiration

    Phosphorylation of glucose and fructose 6-phosphate uses two ATP from the cytoplasm. Glycolysis pay-off phase 4 Substrate-level phosphorylation 2 NADH 3 or 5 Oxidative phosphorylation: Each NADH produces net 1.5 ATP (instead of usual 2.5) due to NADH transport over the mitochondrial membrane Oxidative decarboxylation of pyruvate 2 NADH 5

  9. Malate–aspartate shuttle - Wikipedia

    en.wikipedia.org/wiki/Malate–aspartate_shuttle

    Illustration of the malate–aspartate shuttle pathway. The malate–aspartate shuttle (sometimes simply the malate shuttle) is a biochemical system for translocating electrons produced during glycolysis across the semipermeable inner membrane of the mitochondrion for oxidative phosphorylation in eukaryotes.