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The AP2 adaptor complex is a multimeric protein that works on the cell membrane to internalize cargo in clathrin-mediated endocytosis. [1] It is a stable complex of four adaptins which give rise to a structure that has a core domain and two appendage domains attached to the core domain by polypeptide linkers.
aP2 (adipocyte Protein 2) [5] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs [6] has the possibility of treating heart disease and the metabolic syndrome. [7]
AP2 adaptor complex associates with the plasma membrane and is responsible for endocytosis. [7] AP3 is responsible for protein trafficking to lysosomes and other related organelles. [8] AP4 is less well characterised. AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma).
AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene. [5] This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small ...
Activating protein 2 (AP-2), a mammalian transcription factor Adipocyte protein 2 (aP2), a carrier protein for fatty acids AP2 adaptors (AP-2 complex), which aid clathrin mediated endocytosis
Apetala 2 (AP2) is a gene and a ... As a protein, it regulates the amount of sugars in the system and is involved in transportation, shaping, and signaling.
TFAP2A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) FactorBook AP-2alpha; TFAP2A human gene location in the UCSC Genome Browser. TFAP2A human gene details in the UCSC Genome Browser. This article incorporates text from the United States National Library of Medicine, which is in the public domain
Activating Protein 2 (AP-2) is a family of closely related transcription factors [1] [2] which plays a critical role in regulating gene expression during early development. [ 3 ] References