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C3 convertase (C4bC2b, formerly C4b2a) belongs to family of serine proteases and is necessary in innate immunity as a part of the complement system which eventuate in opsonisation of particles, release of inflammatory peptides, C5 convertase formation and cell lysis.
The C date and time functions are a group of functions in the standard library of the C programming language implementing date and time manipulation operations. [1] They provide support for time acquisition, conversion between date formats, and formatted output to strings.
<noinclude>[[Category:Date conversion templates]]</noinclude> to the end of the template code, making sure it starts on the same line as the code's last character.
Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a central role in the complement system of vertebrate animals and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called C3. [5] [6]
This activated C1 complex cleaves C4 and C2 forming a C4bC2b complex that covalently bonds to the surface of the microbe and functions as a C3 convertase, binding and cleaving C3 into C3a and C3b. Binding of a C3b molecule to the C4bC2b complex (C4b2b3b) results in the formation of a C5 convertase, which cleaves C5 into C5a and C5b.
13137 Ensembl ENSG00000196352 ENSMUSG00000026401 UniProt P08174 Q61476 RefSeq (mRNA) NM_000574 NM_001114543 NM_001114544 NM_001114752 NM_001300902 NM_001300903 NM_001300904 NM_007827 NM_001317361 RefSeq (protein) NP_000565 NP_001108224 NP_001287831 NP_001287832 NP_001287833 NP_001304290 NP_031853 NP_001391877 Location (UCSC) Chr 1: 207.32 – 207.39 Mb Chr 1: 130.32 – 130.35 Mb PubMed search ...
The term C3 convertase may refer to: C3-convertase, an enzyme; Alternative-complement-pathway C3/C5 convertase, an enzyme This page was last edited on 24 January 2021 ...
However, when C3b is distributed in clusters, C3 and C5 convertase activity is generated upon addition of Factors B and D. [3] The classical pathway C5 convertase is composed of the fragments of complement proteins, C4b, C2a produced by cleavage mediated by C1 complex , and C3b produced by cleavage mediated by the classical pathway C3 ...