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These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30] In the EPC trial, at a median follow-up of 7.4 years, breast pain and gynecomastia respectively occurred in 73.6% and 68.8% of men treated with 150 mg/day bicalutamide ...
Orchiectomy, LHRH analogs and LHRH antagonists can all cause similar side effects, due to changes in the levels of sex hormones (testosterone). [17] A program has been developed for patients and their partners to recognize and manage the more burdensome side effects of androgen deprivation therapy.
Some side effects may be ameliorated by using a shorter dosing interval (weekly or every ten days instead of twice monthly with testosterone enanthate or testosterone cypionate). 100 mg weekly gives a much lower peak level of testosterone than does 200 mg every two weeks, while still maintaining the same total dose of androgen.
To reduce the effects of the testosterone flare at the initiation of GnRH agonist therapy in men [50] [51] Androgen-dependent skin and hair conditions such as acne , seborrhea , excessive hair growth , and scalp hair loss in women as well as high testosterone levels due to polycystic ovary syndrome (PCOS) in women, at 25 to 50 mg/day generally ...
What’s more, men with low levels of testosterone at baseline saw an increase in testosterone when taking 5-alpha-reductase inhibitors, but men with high levels of testosterone at baseline didn ...
A 2014 review said there was some evidence men with certain comorbidities may be at risk of adverse effects including sleep apnoea, metabolic syndrome and cardiovascular disease. [29] Exogenous testosterone may also cause suppression of spermatogenesis, leading to, in some cases, infertility. [30]
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