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Common side effects include headache, sleepiness, change in taste, and sore throat. [8] It is unclear if use is safe during pregnancy or breastfeeding. [9] It is a second-generation antihistamine and works by blocking the release of a number of inflammatory mediators including histamine. [7] [8]
The use of sedating drugs alongside hydroxyzine can cause oversedation and confusion if administered at high doses—any form of hydroxyzine treatment alongside sedatives should be done under the supervision of a doctor. [28] [25] Because of the potential for more severe side effects, this drug is on the list to avoid in the elderly. [29]
The safety profile of fexofenadine is quite favorable, as no cardiovascular or sedative effects have been shown to occur even when taking 10 times the recommended dose. [25] Research on humans ranges from a single 800-mg dose, to a twice-daily, 690-mg dose for a month, with no clinically significant adverse effects, when compared to a placebo .
Some common side effects such as drowsiness, dry mouth, and tiredness may occur. Meclizine has been shown to have fewer dry mouth side effects than the traditional treatment for motion sickness, transdermal scopolamine. [16] A very serious allergic reaction to this drug is unlikely, but immediate medical attention should be sought if it occurs.
Side effects experienced while taking cinnarizine range from the mild to the quite severe. Possible side effects include drug-induced parkinsonism, [22] drowsiness, sweating, dry mouth, headache, skin problems, lethargy, gastrointestinal irritation, hypersensitivity reactions, as well as movement problems, muscle rigidity, and tremor. [15]
As such, brain penetration and brain H 1 receptor occupancy by cetirizine are dose-dependent, and in accordance, while cetirizine at doses of 5 to 10 mg have been reported to be non-sedating or mildly sedating, a higher dose of 20 mg has been found to induce significant drowsiness in other studies.
It causes tachycardia by blocking vagal effects on the sinoatrial node. Acetylcholine hyperpolarizes the sinoatrial node; this is overcome by MRAs, and thus they increase the heart rate. If atropine is given by intramuscular or subcutaneous injection, it causes initial bradycardia.
Somnolence (alternatively sleepiness or drowsiness) is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia). It has distinct meanings and causes. It has distinct meanings and causes.