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HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]
HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. Genes in this complex are separated into three basic groups: class I, class II, and class III. In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I.
The class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages). [1]
The frequency of *0101 is 1000 times more abundant than *0103, or 99.9% of the time you have identified the correct allele with the serotype. The false negative rate for HLA-A1 serotype is 1% and the giving the HLA-A1 serotyping a specificity of 98.9% for the A1*0101 allele. Increasing confidence of Interpretation
HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody recognition of α 1 subset of HLA-A α-chains. For A1, the alpha "A" chain are encoded by the HLA-A *01 allele group and the β-chain are encoded by B2M locus. [1] This group currently is dominated by A*01:01.
HLA, the human form of the major histocompatibility complex (MHC), is located on chromosome 6 at 6p21.3. [11] Individuals inherit two different HLA haplotypes, one from each parent, each containing more than 200 genes relevant to helping the immune system recognize foreign invaders. These genes include MHC class I and class II cell-surface ...
There are four commonly encountered DQA1 alleles: DQA1*0101, *0102, *0103, *0104. These alleles are always found in haplotypes with HLA-DQB1*05 and HLA-DQB1*06 . DQ1 is a serotype, rare among serotypes for human class II antigens, in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 allele gene products.
Human leukocyte antigen (HLA) alleles associated with conditions of or affecting the human integumentary system Condition Associated HLA allele(s) Fixed drug eruption: B22 Lichen planus: DR1 DR2 DRw9 DR10 Bw15 B8 Psoriasis: Cw6 DR406 Psoriatic arthritis: B27 Ankylosing spondylitis: B27 Reactive arthritis: B27 Acute anterior uveitis: B27 Behçet ...