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The fetal origins hypothesis (differentiated from the Developmental Origins of Health and Disease hypothesis, which emphasizes environmental conditions both before and immediately after birth) proposes that the period of gestation has significant impacts on the developmental health and wellbeing outcomes for an individual ranging from infancy to adulthood.
The process of DNA methylation is the most studied epigenetic response as it relates to the developmental origins of health and disease. The methylation of chief regulatory cytosines changes the DNA's hydrophobicity and begins to inhibit interactions with transcription factors responsible for the expression of the gene.
The theory of recapitulation, also called the biogenetic law or embryological parallelism—often expressed using Ernst Haeckel's phrase "ontogeny recapitulates phylogeny"—is a historical hypothesis that the development of the embryo of an animal, from fertilization to gestation or hatching (), goes through stages resembling or representing successive adult stages in the evolution of the ...
Morphogenesis also describes the development of unicellular life forms that do not have an embryonic stage in their life cycle. Morphogenesis is essential for the evolution of new forms. Morphogenesis is a mechanical process involving forces that generate mechanical stress, strain, and movement of cells, [ 1 ] and can be induced by genetic ...
The International Society for Developmental Origins of Health and Disease (A International Society for DOHaD), a non-profit organization proposed by David Barker, was set up in 2003 and made up of various scientists and clinicians (31 main council members), whose main research concentration is the developmental origins of health and disease.
The natural history of a disease is sometimes said to start at the moment of exposure to causal agents. [2] Knowledge of the natural history of disease ranks alongside causal understanding in importance for disease prevention and control. Natural history of disease is one of the major elements of descriptive epidemiology. [2]
Cell lineage denotes the developmental history of a tissue or organ from the fertilized egg. [1] This is based on the tracking of an organism's cellular ancestry due to the cell divisions and relocation as time progresses, this starts with the originator cells and finishing with a mature cell that can no longer divide.
The Journal of Developmental Origins of Health and Disease is a bimonthly peer-reviewed medical journal covering the field of Developmental Origins of Health and Disease. It was established in 2010 and is published by Cambridge University Press on behalf of the International Society for Developmental Origins of Health and Disease.