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Examples of methyltransferase enzymes relevant to disease: thiopurine methyltransferase: defects in this gene causes toxic accumulation of thiopurine compounds, drugs used in chemotherapy and immunosuppressant therapy
m4C methyltransferases (N-4 cytosine-specific DNA methylases) are enzymes that specifically methylate the amino group at the C-4 position of cytosines in DNA. [5] Such enzymes are found as components of type II restriction-modification systems in prokaryotes. Such enzymes recognise a specific sequence in DNA and methylate a cytosine in that ...
N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene. [5] METTL3 is located on the human chromosome 14q11.2 (Cancer Biology) and out of the METTL protein family, it is the most studied. [6] This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase.
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is an enzyme that catalyzes the transfer of methyl groups to specific CpG sites in DNA, a process called DNA methylation. In humans, it is encoded by the DNMT1 gene. [5] Dnmt1 forms part of the family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B.
GNMT is an abundant enzyme in liver cytosol and consists of 0.9% to 3% of the soluble protein present in liver. [11] In addition to liver, GNMT activity has been found in a number of other tissues including pancreas and kidney. [9] GNMT is most abundant in the peri-portal region of the liver and exocrine tissue of the pancreas. [11]
Amine N-methyltransferase (EC 2.1.1.49), also called indolethylamine N-methyltransferase, and thioether S-methyltransferase, is an enzyme that is ubiquitously present in non-neural tissues and catalyzes the N-methylation of tryptamine and structurally related compounds. [1]
The enzyme takes the end methyl residue from the methionine side chain and adds it to the side chain carboxyl group of L-isoaspartate or D-aspartate to create a methyl ester. Subsequent nonenzymatic reactions result in a rapid transformation to L -succinimide, which is a precursor to aspartate and isoaspartate.
434437 Ensembl ENSG00000145020 ENSMUSG00000032607 UniProt P48728 Q8CFA2 RefSeq (mRNA) NM_000481 NM_001164710 NM_001164711 NM_001164712 NM_001013814 RefSeq (protein) NP_000472 NP_001158182 NP_001158183 NP_001158184 NP_001013836 Location (UCSC) Chr 3: 49.42 – 49.42 Mb Chr 9: 108.17 – 108.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Aminomethyltransferase Identifiers EC no. 2 ...