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The life cycle often consists of the trypomastigote form in the vertebrate host and the trypomastigote or promastigote form in the gut of the invertebrate host. Intracellular lifecycle stages are normally found in the amastigote form. The trypomastigote morphology is unique to species in the genus Trypanosoma. [citation needed]
The three major human diseases caused by trypanosomatids are; African trypanosomiasis (sleeping sickness, caused by Trypanosoma brucei and transmitted by tsetse flies [3]), South American trypanosomiasis (Chagas disease, caused by T. cruzi and transmitted by triatomine bugs), and leishmaniasis (a set of trypanosomal diseases caused by various species of Leishmania transmitted by sandflies [4]).
Trypanosoma brucei is a species of parasitic kinetoplastid belonging to the genus Trypanosoma that is present in sub-Saharan Africa. Unlike other protozoan parasites that normally infect blood and tissue cells, it is exclusively extracellular and inhabits the blood plasma and body fluids. [ 1 ]
The life cycle of the Trypanosoma brucei parasites. Trypanosoma brucei gambiense accounts for the majority of African trypanosomiasis cases, with humans as the main reservoir needed for the transmission, while Trypanosoma brucei rhodesiense is mainly zoonotic, with accidental human infections. [20]
It is an important vector of Trypanosoma cruzi, the causative agent of Chagas disease. [1] [2] The range of T. gerstaeckeri is from the south-western United States (New Mexico, Texas) to north-eastern Mexico. [3] [4] T. gerstaeckeri goes through three stages during its paurometabolous life cycle: egg, nymphal instars and adult. [5]
Trypanosoma vivax is a parasite species in the genus Trypanosoma. It causes the disease nagana , affecting cattle or wild mammals. It is mainly occurs in West Africa , although it has spread to South America .
In areas where Chagas disease occurs (from the southern United States to northern Argentina), all triatomine species are potential vectors of the Chagas disease parasite Trypanosoma cruzi, but only those species that are well adapted to living with humans (such as Triatoma infestans and Rhodnius prolixus) are considered important vectors.
Triatoma infestans, commonly called winchuka [1] or vinchuca [2] in Argentina, Bolivia, Uruguay and Chile, barbeiro in Brazil, chipo in Venezuela and also known as "kissing bug" or "barber bug" in English, is a blood-sucking bug (like virtually all the members of its subfamily Triatominae) and the most important vector of Trypanosoma cruzi which can lead to Chagas disease.