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Waldenström macroglobulinemia was first described by Jan G. Waldenström (1906–1996) in 1944 in two patients with bleeding from the nose and mouth, anemia, decreased levels of fibrinogen in the blood (hypofibrinogenemia), swollen lymph nodes, neoplastic plasma cells in bone marrow, and increased viscosity of the blood due to increased levels ...
In all events, IgM MGUS is diagnosed in individuals who have serum IgM levels less than 30 gram/liter; have less than 10% of nucleated bone marrow cells with the lymphoplasmacytic morphology, and have no symptoms or findings of end organ dysfunction attributed to Waldenström macroglobulinemia such as anemia, decreases in any white blood cell ...
Others may make blood too viscous to flow smoothly (usually with IgM pentamer macroglobulins), a phenomenon known as Waldenström macroglobulinemia. [citation needed] The most common type of paraproteinemia is monoclonal gammopathy of undetermined significance (MGUS).
Turner was told that he had a blood disorder before being officially diagnosed with Waldenström's macroglobulinemia (WM). According to the American Cancer Society (ACS), WM is a type of non ...
Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. It is a plasma cell dyscrasia , resembling leukemia , with cells of lymphocytic, plasmacytic, or intermediate morphology, which secrete a monoclonal immunoglobulin M component.
Detection of Bence Jones protein may be suggestive of multiple myeloma, [2] or Waldenström's macroglobulinemia. [ citation needed ] Bence Jones proteins are particularly diagnostic of multiple myeloma in the context of target organ manifestations such as kidney failure , lytic (or "punched out") bone lesions, anemia , or large numbers of ...
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