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Symptoms including blurring or loss of vision, headache, and (rarely) stroke or coma are due to the effects of the IgM paraprotein, which may cause autoimmune phenomena or cryoglobulinemia. Other symptoms of Waldenström macroglobulinemia are due to hyperviscosity syndrome, which is present in 6–20% of patients.
Bing–Neel syndrome (BNS) is an extremely rare neurologic complication of Waldenström macroglobulinemia (WM), which is a chronic lymphoproliferative disorder. [1] There's no clear definition of BNS but what is known so far is that unlike WM, It involves the central nervous system (CNS), infiltrated by differentiated malignant B cells and by having hyperglobulinemia. [2]
The incidence of Waldenstrom’s macroglobulinemia ranges from 0.36 1, 2 to 0.57 3 per 100,000 people in the United States or approximately 1,200 to 1,900 annually. With a median disease duration approaching 10 years, 4 approximately 12,000 to 19,000 patients are living with Waldenstrom’s macroglobulinemia in the United States.
Others include cutaneous T-cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, and Waldenström macroglobulinemia. [2] Indolent lymphoma accounts for 41 percent of all non-Hodgkin lymphoma cases in North America and Northern Europe. It mainly affects older adults, and affects men and women almost equally. [4]
Waldenström's macroglobulinemia transforms white blood cells into cancer cells which build up in the bone marrow, the spongy material inside the bones where blood cells are made, according to the ...
Waldenström macroglobulinemia is a slow-silent disease that typically develops when a person is around 65 or older, is male, has a family history of lymphoma, and is caucasian. [6] The condition is called Waldenström macroglobulinemia because the abnormal cells generate excessive levels of IgM which is the biggest immunoglobulin protein, and ...
He was diagnosed with Waldenström's macroglobulinemia, which, according to the Mayo Clinic, "is a type of cancer that begins in the white blood cells. Waldenstrom macroglobulinemia is considered ...
First, it’s important to understand that inflammation isn’t always bad. “Inflammation is one of the body’s key mechanisms for maintaining homeostasis, acting as a natural response to ...