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There was high impact score of rs11235972 GG genotype thus showing association of UCP3 gene polymorphism and nonalcoholic fatty liver disease in Chinese children (Xu YP et al., 2013) The research of counterfeits in two independent population there was a similarity between the -55CT mutation of UCP3 and lower BMI.
In contrast to UCP1 and UCP3, which are primarily expressed in adipose and smooth muscle, UCP2 is expressed on many different tissues [6] including the kidney, liver, GI tract, brain, and skeletal muscle. The exact mechanisms of anion transfer by UCPs are not known. [7] UCPs contain the three homologous protein domains of MACPs.
UCP3 also reduces the risk of type 1 diabetes, indicating UCPs prevent mitochondrial-mediated neuronal injury (Kumar, 2022). The capacity to control elements affected by energy balance, such as 3-adrenoreceptor agonists, food intake, and exposure to cold, is shared by UCPs 1, 2, and 3. Lastly, cardiovascular disease is associated with UCP3.
22227 Ensembl ENSG00000109424 ENSMUSG00000031710 UniProt P25874 P12242 RefSeq (mRNA) NM_021833 NM_009463 RefSeq (protein) NP_068605 NP_033489 Location (UCSC) Chr 4: 140.56 – 140.57 Mb Chr 8: 84.02 – 84.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial ...
269523 Ensembl ENSG00000165280 ENSMUSG00000028452 UniProt P55072 Q01853 RefSeq (mRNA) NM_007126 NM_001354927 NM_001354928 NM_009503 RefSeq (protein) NP_009057 NP_001341856 NP_001341857 NP_033529 Location (UCSC) Chr 9: 35.05 – 35.07 Mb Chr 4: 42.98 – 43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Valosin-containing protein (VCP) or transitional endoplasmic reticulum ATPase ...
Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene. [5] [6] [7]Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP).
Antonio Vidal-Puig, Spanish scientist. Antonio Vidal-Puig (born Valencia, Spain June 12, 1962) is a Spanish medical doctor and scientist who works as a Professor of Molecular Nutrition and Metabolism at the University of Cambridge (), best known for advancing the concept that pharmacological targeting of brown fat may serve to treat overweight and obesity in affected individuals, [1] as well ...
Brown fat cells come from the middle embryo layer, mesoderm, also the source of myocytes (muscle cells), adipocytes, and chondrocytes (cartilage cells). The classic population of brown fat cells and muscle cells both seem to be derived from the same population of stem cells in the mesoderm, paraxial mesoderm.