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Allopurinol has rare but potentially fatal adverse effects involving the skin. The most serious adverse effect is a hypersensitivity syndrome consisting of fever, skin rash, eosinophilia, hepatitis, and worsened renal function, collectively referred to as DRESS syndrome. [23]
Allopurinol hypersensitivity syndrome (AHS) typically occurs in persons with preexisting kidney failure. [3]: 119 Weeks to months after allopurinol is begun, the patient develops a morbilliform eruption [3]: 119 or, less commonly, develops one of the far more serious and potentially lethal severe cutaneous adverse reactions viz., the DRESS syndrome, Stevens Johnson syndrome, or toxic epidermal ...
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...
It is generally recommended only for people who cannot take allopurinol. [8] [9] It is taken by mouth. [7] Common side effects include liver problems, nausea, joint pain, and a rash. [7] Serious side effects include an increased risk of death as compared with allopurinol, Stevens–Johnson syndrome, and anaphylaxis.
Certain beverages can complement the effects of weight loss medications, support hydration and provide essential nutrients, while others may lead to unwanted side effects or make it harder to lose ...
Benzbromarone is a uricosuric agent and non-competitive inhibitor of xanthine oxidase [1] used in the treatment of gout, especially when allopurinol, a first-line treatment, fails or produces intolerable adverse effects. It is structurally related to the antiarrhythmic amiodarone. [2]
Potential risks: Some negative side effects like muscle cramps, facial swelling, and bloating have been reported in relation to medication interactions, as well as for some people with existing ...
But some research has noted rare but serious side effects of once-weekly, 2.4-milligram (mg) semaglutide injections, such as pancreatitis, acute kidney injury, gallbladder issues, and thyroid cancer.