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Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
The post Why I Started and Stopped Taking the “Anti-Aging” Drug Rapamycin appeared first on AGEIST. Addressing my health, fitness, and longevity has been a priority for me for at least fifteen ...
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
This compound also has a use in cardiovascular drug-eluting stent technologies to inhibit restenosis. [ medical citation needed ] It is the 40- O -(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR).
Compared to them, the mortality rate was 4% higher for those who took multivitamins daily and 9% higher for those who took them less often. Younger vitamin users had the highest risk.
Data from three large clinical trials published in 2018 found that, while there was a small benefit of taking daily aspirin for heart health, there was also an increased risk of developing ...
The discovery of TSC1/2 gene function as negative regulator of the mammalian target of rapamycin complex 1 (mTORC1) [33] [34] led to successful use of rapamycin analog sirolimus in clinical trials [35] [36] and FDA approval of sirolimus for treatment of LAM.
Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]