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Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent , and gadolinium (Gd 3+ ), and is used in form of the meglumine salt (gadoterate meglumine).
The animals were administered multiple doses repeatedly over days, therefore, their exposure levels were much higher than those experienced in humans. [8] Gadobutrol should only be administered in pregnant females if the potential benefit outweighs the risk to the fetus. [8] [10]
DOTA is derived from the macrocycle known as cyclen.The four secondary amine groups are modified by replacement of the N-H centers with N-CH 2 CO 2 H groups. The resulting aminopolycarboxylic acid, upon ionization of the carboxylic acid groups, is a high affinity chelating agent for di- and trivalent cations.
NAD supplement benefits Aging and many diseases are associated with reduced NAD+ levels. There is ongoing research into the effects of NAD supplementation and potential uses.
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Gadoxetic acid is a gadolinium-based MRI contrast agent. [4] Its salt, gadoxetate disodium , is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals .
Gadobenic acid (INN, brand name Multihance) is a complex of gadolinium with the ligand BOPTA. In the form of the methylglucamine salt meglumine gadobenate ( INNm ) or gadobenate dimeglumine ( USAN ), it is used as a gadolinium-based MRI contrast medium .
Iodized oil, also known as ethiodized oil, brand name Lipiodol, is a medication derived from poppyseed oil and iodine.When given by injection, it is a radio-opaque contrast agent that is used to outline structures in radiological investigations.