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Osaterone acetate is used in veterinary medicine for the treatment of benign prostatic hyperplasia (BPH) in dogs. [3] [5] [6] It has been found to produce remission of clinical symptoms of BPH in 83% of dogs for six months after a single one-week course of treatment, [9] and can be used long-term.
In progestogen induced hypersomatotropism the prognosis is usually good after cessation of progestogen administration. In dogs soft tissue changes are usually resolved in a few weeks or months, persistent bone changes usually do not cause clinical problems. For diabetes mellitus the prognosis for the condition depends on the beta cell damage. [1]
A progestogen, also referred to as a progestagen, gestagen, or gestogen, is a type of medication which produces effects similar to those of the natural female sex hormone progesterone in the body. [1] A progestin is a synthetic progestogen. [1] Progestogens are used most commonly in hormonal birth control and menopausal hormone therapy. [1]
Proligestone is used to control estrus in dogs and cats and has also been used to treat ... Proligestone is a progestogen, or an agonist of the progesterone ...
The use of progesterone tests in dog breeding to pinpoint ovulation is becoming more widely used. There are several tests available but the most reliable test is a blood test with blood drawn by a veterinarian and sent to a lab for processing. Results can usually be obtained with 24 to 72 hours.
DMA is a progestogen with antigonadotropic and hence antiandrogenic and antiestrogenic effects. In addition, DMA binds to the androgen receptor , and likely acts as an antagonist of this receptor similarly to related drugs like chlormadinone acetate and osaterone acetate .
Overdose causes only harmless side effects such as nausea and vaginal bleeding. [19] The LD 50 has been found to range between 500 mg/kg in dogs and over 3000 mg/kg in rats. Chronic toxicity has been examined in animals, but nothing but the typical adverse effects of progestogens, and reduction of prostatic weight in rhesus monkeys, have been ...
OHPA is a progestogen and acts as an agonist of the progesterone receptor (PR), both PR A and PR B isoforms (IC 50 = 16.8 nM and 12.6 nM, respectively). [15] It has more than 50-fold higher affinity for the PR isoforms than 17α-hydroxyprogesterone, a little less than half the affinity of progesterone, and slightly higher affinity than OHPC. [16]