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Due to these side effects and its red color, doxorubicin has earned the nickname "red devil" [24] [25] or "red death." [26] Chemotherapy can cause reactivation of hepatitis B, and doxorubicin-containing regimens are no exception. [27] [28] Doxorubicin and several chemotherapeutic drugs (including cyclophosphamide) can cause a loss of skin ...
Currently, there are two liposomal formulations of doxorubicin available in the clinics. Doxil/Caelyx is the first FDA approved liposomal DDS, and was initially used to treat AIDS-related Kaposi’s sarcoma in 1995 and is now being used for treating recurrent ovarian cancer, metastatic breast cancer with increased cardiac risk, and multiple ...
In the case of PPE caused by pegylated liposomal doxorubicin , the following mechanism has been demonstrated: sweat deposits and spreads the drug on the skin surface; then the drug penetrates into the stratum corneum like an external agent; palms and soles have high density of sweat glands, and their stratum corneum is approximately 10 times ...
Cardiotoxicity (heart damage) is especially prominent with the use of anthracycline drugs (doxorubicin, epirubicin, idarubicin, and liposomal doxorubicin). The cause of this is most likely due to the production of free radicals in the cell and subsequent DNA damage .
Side effects include irregular heartbeat, fatigue, high blood pressure, dry mouth, and eyes that are itchy, red, and/or swollen. Carbonic anhydrase inhibitors (Trusopt, Azopt): This is another ...
Enhanced permeability and retention (EPR) effect and passive targeting. The enhanced permeability and retention (EPR) effect is a controversial concept [1] [2] by which molecules of certain sizes (typically liposomes, nanoparticles, and macromolecular drugs) tend to accumulate in tumor tissue much more than they do in normal tissues.
Move over, Wordle, Connections and Mini Crossword—there's a new NYT word game in town! The New York Times' recent game, "Strands," is becoming more and more popular as another daily activity ...
"Hearst Magazines and Yahoo may earn commission or revenue on some items through these links." Alzheimer’s disease, the most common form of dementia affecting more than three million Americans a ...