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Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors , which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia due to bone marrow insufficiency.
"Moon blindness" on an Icelandic horse Advanced stage of disease Advanced stage of disease ERU on an Icelandic horse. Equine recurrent uveitis (ERU) – also known as moon blindness, recurrent iridocyclitis, or periodic ophthalmia [1] – is an acute, nongranulomatous inflammation of the uveal tract of the eye, occurring commonly in horses of all breeds, worldwide.
praziquantel – treatment of infestations of the tapeworms Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus; prazosin – sympatholytic used in hypertension and abnormal muscle contractions; prednisolone – glucocorticoid (steroid) used in the management of inflammation and auto-immune disease, primarily in cats
This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed ...
A horse may be returned to work if symptoms have ceased and is no longer on NSAIDs or other prescribed drugs related to treatment of ER, this can otherwise can hide signs of another bout of ER. If NSAIDs or other treatment drugs are needed to keep the horse comfortable, or if the horse is reluctant to continue work, the animal is not yet ready ...
Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration. [ 4 ] Halofuginone inhibits the development of T helper 17 cells , immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T ...
A short, 5-day course of FcR-binding, anti-CD3 antibody treatment was able to re-establish peripheral tolerance in animal models of autoimmune disease, thereby completely reversing disease. The mechanism of action caused systemic depletion of T-cells from the blood and sites of inflammation.
The first is Immune-Mediated Myositis (IMM). It may occur in response to a vaccine or infectious agent, where the immune system misinterprets the muscle cells as foreign and rapidly attacks them. Horses initially experience stiffness, weakness, and a decreased appetite followed by the rapid loss of 40% of muscle mass within 72 hours.