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Prochlorperazine is thought to exert its antipsychotic effects by blocking dopamine receptors. [29] Prochlorperazine is analogous to chlorpromazine; both of these agents antagonize dopaminergic D 2 receptors in various pathways of the central nervous system. This D 2 blockade results in antipsychotic, antiemetic and other effects.
QT prolongation is a measure of delayed ventricular repolarisation, which means the heart muscle takes longer than normal to recharge between beats. It is an electrical disturbance which can be seen on an electrocardiogram (EKG). Excessive QT prolongation can trigger tachycardias such as torsades de pointes (TdP).
Prochlorperazine and desferrioxamine may also interact with chlorpromazine to produce transient metabolic encephalopathy. [ 5 ] Other drugs that prolong the QT interval, such as quinidine , verapamil , amiodarone , sotalol and methadone , may also interact with chlorpromazine to produce additive QT interval prolongation.
From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN).
There's growing evidence to suggest that GLP-1 drugs, which include Ozempic's semaglutide, may be useful for treating alcohol use disorder.
A new opioid-free pain medication was approved by the U.S. Food and Drug Administration (FDA) on Thursday, marking a non-addictive alternative for patients. Journavx (suzetrigine), made by Vertex ...
The Quaker Oats Co. has recalled 10,000 boxes of pancake mix because it contains milk not declared on the label and could pose a risk of potentially dangerous allergic reactions. The Chicago-based ...
In 2001, the FDA changed the labeling requirements for droperidol injection to include a Black Box Warning, citing concerns of QT prolongation and torsades de pointes.The evidence for this is disputed, with 9 reported cases of torsades in 30 years and all of those having received doses in excess of 5 mg. [9] QT prolongation is a dose-related effect, [10] and it appears that droperidol is not a ...