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Acute inflammation of the lung (usually in response to pneumonia) does not cause pain unless the inflammation involves the parietal pleura, which does have pain-sensitive nerve endings. [15] Heat and redness are due to increased blood flow at body core temperature to the inflamed site.
Chronic systemic inflammation is the result of release of pro-inflammatory cytokines from immune-related cells and the chronic activation of the innate immune system.It can contribute to the development or progression of certain conditions such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, autoimmune and neurodegenerative ...
Chronic inflammation, by contrast, is more long-term. This ongoing state where the body's immune response is continuously active may be due to illness, or it may even occur without a clear issue.
Inflammaging is thought to be caused by a loss of control over systemic inflammation resulting in chronic overstimulation of the innate immune system. Inflammaging is a significant risk factor in mortality and morbidity in aged individuals. [2] [3] [4] Inflammation is essential to protect against viral and bacterial infection, as well as ...
Painful joints can have a significant impact on quality of life and the ability to do daily activities. Joint pain is a common symptom we all experience at some point or another. Painful joints ...
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [1] Pain and stiffness often worsen following rest. [1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [1]
Wrist mobility is often restricted due to inflammation of the forearm muscles as they contract and tighten due to injury. [2] Most wrist dislocations occur between the capitate and the lunate. [17] [18] Carpal fractures are caused by falling on an outstretched hand the wrist is hyper-extended in ulnar deviation with a component of rotation. [18]
Diagnosis is by biopsy of moisture-producing glands and blood tests for specific antibodies. [2] On biopsy there are typically lymphocytes within the glands. [2] The cause of Sjögren's syndrome is unknown, but it may be the influence of a combination of genetic, environmental, and other factors, as is the case with many other autoimmune ...