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The results of this test must be interpreted carefully. The person's medical risk factors determine at which increment (5 mm, 10 mm, or 15 mm) of induration the result is considered positive. [12] A positive result indicates TB exposure. 5 mm or more is positive in An HIV-positive person; Persons with recent contacts with a TB patient
A meta-analysis with 1,595 inpatients and outpatients showed 70% sensitivity and 90% specificity for TB diagnosis in people living with HIV for Fujifilm SILVAMP TB LAM. [40] As of 2020, the test showed a high positive predictive value (95.2%) in HIV-negative outpatients. [41] Large prospective studies are on the way. [42]
The equivalent Mantoux test positive levels done with 10 TU (0.1 mL 100 TU/mL, 1:1000) are 0–4 mm induration (Heaf 0-1) 5–14 mm induration (Heaf 2) >15 mm induration (Heaf 3-4) The Mantoux test is preferred in the United States for the diagnosis of tuberculosis; multiple puncture tests, such as the Heaf test and Tine test, are not recommended.
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[119] [120] [121] Part of the reasoning against the use of the vaccine is that it makes the tuberculin skin test falsely positive, reducing the test's usefulness as a screening tool. [121] Several vaccines are being developed. [14] Intradermal MVA85A vaccine in addition to BCG injection is not effective in preventing tuberculosis. [122]
Persons with these findings, if they have a positive tuberculin skin test reaction, should be considered high-priority candidates for treatment of latent infection regardless of age. Conversely, calcified nodular lesions (calcified granuloma ) pose a very low risk for future progression to active tuberculosis.
The tine test is a multiple-puncture tuberculin skin test used to aid in the medical diagnosis of tuberculosis (TB). The tine test is similar to the Heaf test, although the Mantoux test is usually used instead. There are various forms of the tine tests which usually fall into two categories: the old tine test (OT) and the purified protein ...
TB positive, indicating a sensitivity of 97.2%. [3] However, more recent data from a study in children with active TB disease in the UK suggest that the sensitivity of the T-SPOT. TB may in fact be worse than that of the tuberculin skin test (sensitivity reported as 66% and 82%, respectively). [ 4 ]