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[9] [10] Overdose of only a small number of capsules can be fatal. [10] Chewing or sucking on the capsule, releasing the drug into the mouth, can also lead to laryngospasm, bronchospasm, and circulatory collapse. [7] It is unclear if use in pregnancy or breastfeeding is safe. [11] Benzonatate is a local anesthetic and voltage-gated sodium ...
The drug acts as an antagonist at muscarinic receptors [3] (subtype M 1) and as an agonist at sigma receptors (subtype σ 1) [6] with an IC 50 of 9 nM. [10] Its anticholinergic properties can theoretically relax the pulmonary alveoli and reduce phlegm production. Spasmolytic and local anaesthetic properties have also been described. [5]
However, it is confusing when referring benzonatate as the only "non-narcotic antitussive" because narcotic in the Greek sense could refer to diphenhydramine (or Benadryl) which can be used for cough and is significantly sedating. Given all of this, it seems the best term for benzonatate would be "non-opioid antitussive" to avoid this confusion.
Modified-release dosage and its variants are mechanisms used in tablets (pills) and capsules to dissolve a drug over time in order to be released more slowly and steadily into the bloodstream, while having the advantage of being taken at less frequent intervals than immediate-release (IR) formulations of the same drug.
capsule cap. capiat: let him take (let the patient take) c.m. cras mane: tomorrow morning c.m.s. cras mane sumendus: to be taken tomorrow morning c̄, c. cum: with (usually written with a bar on top of the c) cib. cibus: food c.c. cum cibo: with food [or] cubic centimetre
CAIRO (Reuters) -Israeli military strikes killed at least 27 Palestinians across the Gaza Strip on Friday, medics said, as health officials resumed vaccination of tens of thousands more children ...