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Mycophenolate mofetil, a prodrug form of mycophenolic acid used in medicine. Mycophenolate mofetil is the morpholino ethyl ester of mycophenolic acid; the ester masks the carboxyl group. [42] Mycophenolate mofetil is reported to have a pKa values of 5.6 for the morpholino moiety and 8.5 for the phenolic group.
Mycophenolate mofetil is the prodrug of mycophenolic acid (MPA) and widely used for the prevention of acute rejection after solid organ transplantation. MPA could be metabolized to AcMPAG, which is responsible for adverse effects of MMF therapy such as leucopenia or gastrointestinal toxicity.
Mycophenolic acid acts as a non-competitive, selective, and reversible inhibitor of inosine-5′-monophosphate dehydrogenase (IMPDH), which is a key enzyme in the de novo guanosine nucleotide synthesis. In contrast to other human cell types, lymphocytes B and T are very dependent on this process.
The U.S. Food and Drug Administration (FDA) on Thursday approved a new type of prescription pain medication for adults to treat moderate to severe acute pain. The drug, called Journavx ...
Foods that reduce inflammation include fatty fish, tea, walnuts, and more. Here, a dietitian explains the best anti-inflammatory foods to eat.
If one has asthma, it's commonly triggered by exercise, cold air (or sudden temperature changes), acid reflux, respiratory infections (even the common cold), breathing in chemicals from smoke ...