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Leucine Zipper Transcription Regulator Protein Structure. Leucine-zipper-like transcriptional regulator 1 is a protein that in humans is encoded by the LZTR1 gene. [5] [6] [7]The LZTR1 gene provides instructions for making a protein among the class of the superfamily broad complex, tamtrack & brick-a-bac / poxvirus and zinc finger (BTB/POZ).
Neurofibromatosis type II (also known as MISME syndrome – multiple inherited schwannomas, meningiomas, and ependymomas) is a genetic condition that may be inherited or may arise spontaneously, and causes benign tumors of the brain, spinal cord, and peripheral nerves.
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The three types of neurofibromatosis are caused by different mutations on chromosomes. NF1 is caused by a mutation on the NF1 gene on the arm of chromosome 17. [4] NF2 is caused by a mutation on the NF2 tumor suppressor gene on chromosome 22. [4] Schwannomatosis is caused by various mutations on chromosome 22. [4]
LGMD is a genetic and heritable disorder, due to one of many genetic mutations of proteins involved in muscle function. All currently identified LGMDs have an inheritance pattern that is dominant or recessive , although the definition of LGMD allows for diseases with more complicated inheritance patterns to be classified as LGMD.
Diseases caused by different mutations within the 3′-UTR. 3′-UTR mutations can be very consequential because one alteration can be responsible for the altered expression of many genes. Transcriptionally, a mutation may affect only the allele and genes that are physically linked.
Early research on somatic mutations in aging showed that deletions, inversion, and translocations of genetic material are common in aging mice and aging genomes tend to contain visible chromosomal changes, mitotic recombination, whole gene deletions, intragenic deletions, and point mutations.
Sequentially ordered mutations accumulate in driver genes, tumour suppressor genes, and DNA repair enzymes, resulting in clonal expansion of tumour cells. Linear expansion is less likely to reflect the endpoint of a malignant tumour [ 30 ] because the accumulation of mutations is stochastic in heterogeneic tumours.