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In the United States, six high-intensity sugar substitutes have been approved for use: aspartame, sucralose, neotame, acesulfame potassium (Ace-K), saccharin, and advantame. [3] Food additives must be approved by the FDA, [ 3 ] and sweeteners must be proven as safe via submission by a manufacturer of a GRAS document. [ 44 ]
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In the European Union, it is known under the E number (additive code) E950. [3] It was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG (now Nutrinova). [4] Acesulfame potassium is the potassium salt of 6-methyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide. It is a white crystalline powder with molecular formula C
Texas, Florida, New York, and Pennsylvania round out the top five states for pharmacy locations. [1] Nationwide, the number of community pharmacies increased by 6.3% between 2007-2015, and the number of pharmacies per 10,000 people (2.11) did not change.
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Pepsi Zero Sugar (sold under the names Diet Pepsi Max until 2009 and Pepsi Max until August 2016), is a zero-calorie, sugar-free, formerly ginseng-infused cola [1] sweetened with aspartame and acesulfame K, marketed by PepsiCo. It originally contained nearly twice the caffeine of Pepsi's other cola beverages. [2]
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