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Feathery degeneration - large cells with pale flocculant cytoplasm (left-bottom and right-top). H&E stain . In histo pathology , feathery degeneration , formally feathery degeneration of hepatocytes , is a form of liver parenchymal cell (i.e. hepatocyte ) death associated with cholestasis .
Histopathology of a ballooning hepatocyte.png, H&E stain. Ballooning degeneration centre-left and centre-right. H&E stain. A Councilman body can also be seen in the upper-right of the section. In histo pathology, ballooning degeneration, formally ballooning degeneration of hepatocytes, is a form of liver parenchymal cell (i.e. hepatocyte) death.
Councilman body (upper-right) and ballooning degeneration (centre-left). H&E stain. In pathology, a Councilman body, also known as a Councilman hyaline body or apoptotic body, is an eosinophilic globule of apoptotic hepatocyte cell fragments. Ultimately, the fragments are taken up by macrophages or adjacent parenchymal cells. [1]
Piecemeal necrosis in liver aka interface hepatitis is necrosis of the limiting plates, by inflammatory cells. It may be identified as actual necrosis of cells or by irregularity of the limiting plates which is caused IOS's hepatocytes and replacement with inflammatory cells and/or fibrosis.
Hepatocyte necrosis is not a significant feature of cholestasis; however, apoptosis may often occur. [90] Under the microscope, hepatocytes in the perivenular zone appear enlarged and flocculent. [88] In cases of obstructive cholestasis, bile infarcts may be produced during the degeneration and necrosis of hepatocytes. [90]
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Hepatocytes constitute about 80% of the cell population of the liver, with the other 20% being occupied by Kupffer cells, hepatic stellate cells, endothelial cells and mesothelial cells, which are not exactly characteristic of the liver, but are present in the liver samples. [2] Histologically speaking, hepatocytes have specific characteristics.
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