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Dronabinol (INN Tooltip International Nonproprietary Name), sold under the brand names Marinol and Syndros, is the generic name for the molecule of (−)-trans-Δ 9-tetrahydrocannabinol (THC) in the pharmaceutical context.
DE: Dronabinol: Anlage III, Δ 9-THC: II, other isomers and their stereochemical variants: I. (Does not apply to THC as part of cannabis, which is regulated separately, see Cannabis (drug)) UK: Class B; US: Schedule II as Syndros, Schedule III as Marinol, [2] Schedule I as Δ 9-THC in pure form. UN: Psychotropic Schedule I /II; In general Rx-only
Dronabinol/acetazolamide (investigational name IHL-42X) is a combination therapy under investigation for sleep apnea. It is developed by Incannex Healthcare. It is developed by Incannex Healthcare. [ 1 ] [ 2 ]
THC hemisuccinate (Δ 9-THC-O-hemisuccinate, Dronabinol hemisuccinate) is a synthetic derivative of tetrahydrocannabinol, developed in the 1990s. It is a water-soluble prodrug ester which is converted into THC inside the body, and was developed to overcome the poor bioavailability of THC when taken by non-inhaled routes of administration .
Dronabinol (brand names Marinol and Syndros) is a delta-9-THC containing drug for treating HIV/AIDS-induced anorexia and chemotherapy-induced nausea and vomiting. [58] The CBD drug Epidiolex has been approved by the Food and Drug Administration for treatment of two rare and severe forms of epilepsy, [59] Dravet and Lennox-Gastaut syndromes. [60]
Classical cannabinoids include nabilone and dronabinol, and one of the best known synthetic classical cannabinoids is HU-210. [85] HU-210 is a chiral compound first synthesized by Raphael Mechoulam at Hebrew University in the 1980s.
On October 18, 1985, the DEA issued a Notice of Proposed Rulemaking to transfer "Synthetic Dronabinol in Sesame Oil and Encapsulated in Soft Gelatin Capsules" — a pill form of Δ 9-tetrahydrocannabinol, the main psychoactive component of cannabis, sold under the brand name Marinol — from Schedule I to Schedule II (DEA 50 FR 42186-87).
Δ-8-tetrahydrocannabinol (delta-8-THC, [a] Δ 8-THC) is a psychoactive cannabinoid found in the cannabis plant. [1] It is an isomer of delta-9-tetrahydrocannabinol (delta-9-THC, Δ 9-THC), the compound commonly known as THC, with which it co-occurs in hemp; natural quantities of ∆ 8-THC found in hemp are low.