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Unlike other major East Coast cities, such as New York City and Boston, Center City Philadelphia, originally the core of Philadelphia's white-collar workforce, has seen a marked decline in jobs, as companies have gradually relocated to the suburbs. As of 2019, Center City had approximately 180,000 daily commuters from the suburbs.
I-44 enters the St. Louis region in Sullivan, Missouri, and runs eastward through Franklin and St. Louis counties, briefly merging with I-55 in the city of St. Louis, and terminating at I-70. The "beltway" serving Greater St. Louis is the combination of Interstate 270 and Interstate 255, the former a mostly western bypass of St. Louis
The route runs southwest to northeast and serves as a major arterial road through the city of Philadelphia and for many of the suburbs in the Delaware Valley metropolitan area. South of Philadelphia, the road mostly follows the alignment of the Baltimore Pike. Within Philadelphia, it mostly follows Roosevelt Boulevard.
The Roosevelt Boulevard begins at an intersection with Hunting Park Avenue, continuing northeast as a part of US 13. The road crosses Broad Street (PA 611) before US 1 (Roosevelt Expressway) merges in at an interchange and Roosevelt Boulevard becomes a 12-lane surface arterial with local and express lanes and at-grade intersections, carrying US 1 and US 13.
U.S. Route 40 (US 40) in the state of Missouri is a U.S. highway that runs from Kansas City to St. Louis. Outside of Greater St. Louis , much of the route either parallels or runs along I-70 . East of Wentzville in Greater St. Louis, the route runs along I-64 .
Interstate 676 (I-676) is an Interstate Highway that serves as a major thoroughfare through Center City Philadelphia, where it is known as the Vine Street Expressway, and Camden, New Jersey, where it is known as the northern segment of the North–South Freeway, as well as the Martin Luther King Jr. Memorial Highway in honor of civil rights leader Martin Luther King Jr.
Route 100, also named Manchester Road through St. Louis County and Manchester Avenue and Chouteau Avenue through St. Louis City, is a state highway in the U.S. state of Missouri. It runs from Linn, Missouri at U.S. Route 50 to Interstate 55 in St. Louis. The highway is 121 miles (195 km) long.
I-95 southbound approaching the I-676/US 30 interchange in Center City Philadelphia. Past the Schuylkill River, I-95 continues east into South Philadelphia as an elevated freeway through industrial areas to the north of The Navy Yard, a mixed-use development that is located at the former Philadelphia Naval Shipyard.