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Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. [18] It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not recommended in elderly patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura ...
A 2024 cohort study of ICI use during pregnancy showed no overreporting of specific adverse effects on pregnancy, fetal, and/or newborn outcomes, interestingly. [ 157 ] Using a mouse model of bladder cancer, researchers have found that a local injection of a low dose anti-CTLA-4 in the tumour area had the same tumour inhibiting capacity as when ...
In combination with monoclonal antibody Rituximab it is called R-ESHAP or ESHAP-R. [1] R-ESHAP consists of: Rituximab, an anti-CD20-directed monoclonal antibody that kills both normal and malignant B-lymphocytes; Etoposide, an epipodophyllotoxin topoisomerase inhibitor; Solu-Medrol - Methylprednisolone, which is a glucocorticoid that can lyse ...
Other side effects include allergic reactions, kidney problems, and a very small risk of viral infections. [2] In those with ITP, the amount of red blood cell breakdown may be significant. [2] Use is safe with breastfeeding. [2] Rho(D) immune globulin is made up of antibodies to the antigen Rh o (D) present on some red blood cells. [2]
In combination with Rituximab, this regimen is called R-FCM or R-FMC, or FCM-R, FMC-R. The [R]-FCM regimen contains Rituximab - anti-CD20 monoclonal antibody that can kill both normal and malignant CD20-bearing B cells; Fludarabine - an antimetabolite; Cyclophosphamide - an alkylating antineoplastic agent from the oxazafosforine group;
There are several modifications of CEPP. In combination with bleomycin, this regimen is called CEPP (B). [2] With the further addition of the anti-CD20 monoclonal antibody rituximab, it is called R-CEPP(B). R-CEPP(B) regimen consists of: Rituximab - a monoclonal antibody that is able to kill CD20-positive B cells, either normal or malignant
B-cell lymphoma-2 (BCL-2) inhibitor, venetoclax, plus a CD20 antibody obinutuzumab, OR BTKi (i.e. ibrutinib) plus BCL-2 inhibitor (i.e. venetoclax) [ 15 ] [ 16 ] [ 17 ] The medications fludarabine , cyclophosphamide , and rituximab were previously the initial treatment in those who are otherwise healthy.
Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and increase life expectancy. For these regimens, in general, a better toxicity profile is expected. [6]: 55–59 All chemotherapy regimens require that the recipient be capable of undergoing the treatment.