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Cleft lip and palate is one of the most common occurring multi-factorial congenital disorder occurring in 1 in 500–1000 live births in several forms. [ 8 ] [ 9 ] [ 10 ] The most common form is combined cleft lip and palate and it accounts for approximately 50% of cases, whereas isolated cleft lip concerns 20% of the patients.
Maxillary hypoplasia is the most common secondary deformity that results from cleft lip and cleft palate. Because of the subjective nature of the diagnosis, the incidence of maxillary hypoplasia in people with cleft lip and palate varies between 15-50%. It is estimated that 25-50% of these patients require surgical intervention. [7]
The shelves will also fuse anteriorly upon the primary palate, with the incisive foramen being the landmark between the primary palate and secondary palate. This forms what is known as the roof of the mouth, or the hard palate. The formation and development of the secondary palate occurs through signalling molecules SHH, BMP-2, FGF-8, among others.
This arch divides into a maxillary process and a mandibular process, giving rise to structures including the bones of the lower two-thirds of the face and the jaw. The maxillary process becomes the maxilla (or upper jaw, although there are large differences among animals [11]), and palate while the mandibular process becomes the mandible or lower jaw.
General patterns of dental morphological evolution throughout human evolution include a reduction in facial prognathism, the presence of a Y5 cusp pattern, the formation of a parabolic palate and the loss of the diastema. Human teeth are made of dentin and are covered by enamel in the areas that are exposed. [2]
Submucous cleft palate can also occur, which is a cleft of the soft palate with a split uvula, a furrow along the midline of the soft palate, and a notch in the back margin of the hard palate. [12] The diagnosis of submucous cleft palate often occurs late in children as a result of the nature of the cleft. [ 13 ]
The palate (/ ˈ p æ l ɪ t /) is the roof of the mouth in humans and other mammals. It separates the oral cavity from the nasal cavity . [ 1 ] A similar structure is found in crocodilians , but in most other tetrapods , the oral and nasal cavities are not truly separated.
Papilliary hyperplasia of the palate, or epulis fissaratum/denture-induced hyperplasia. The cause may be unknown, but there is an association with ill-fitting dentures resulting in irritation to the mucosa, usually by overextended flange, and with poor denture or oral hygiene. Oral thrush can be present but is not thought to be the cause.