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An acidic group like tetrazole, CO 2 H or NHSO 2 CF 3 at the 1-position of the biphenyl-methyl group will bind to a basic position in the receptor and are required for potent antagonistic activity. [19] In valsartan, the imidazole ring of losartan has been replaced with an acylated amino acid. [4]
A contingent convertible bond (CoCo), also known as an enhanced capital note (ECN), [1] is a fixed-income instrument that is convertible into equity if a pre-specified trigger event occurs. [2] The concept of CoCo has been particularly discussed in the context of crisis management in the banking industry. [ 3 ]
Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...
AT1 may refer to: Angiotensin II receptor type 1; Additional Tier 1 capital, see Contingent convertible bond; Yamaha AT1 (1969-1971) motorcycle; Ekspress AT1, communications satellite AT1 in the Ekspress network; AeroTech Release 1; tabletop wargame
In chemistry, ligand close packing theory (LCP theory), sometimes called the ligand close packing model describes how ligand – ligand repulsions affect the geometry around a central atom. [1] It has been developed by R. J. Gillespie and others from 1997 onwards [ 2 ] and is said to sit alongside VSEPR [ 1 ] which was originally developed by R ...
Angiotensin II receptor type 1 (AT1) is a G q/11-coupled G protein-coupled receptor (GPCR) and the best characterized angiotensin receptor. It is encoded in humans by the AGTR1 gene. AT1 has vasopressor effects and regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system.
In organic chemistry, neighbouring group participation (NGP, also known as anchimeric assistance) has been defined by the International Union of Pure and Applied Chemistry (IUPAC) as the interaction of a reaction centre with a lone pair of electrons in an atom or the electrons present in a sigma or pi bond contained within the parent molecule but not conjugated with the reaction centre.
2. In (a) the two nuclei are surrounded by a cloud of two electrons in the bonding orbital that holds the molecule together. (b) shows hydrogen's antibonding orbital, which is higher in energy and is normally not occupied by any electrons. A chemical bond is the association of atoms or ions to form molecules, crystals, and other