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Targeted agents are beginning to permit the design of more rational treatment regimens for non-small cell lung cancer (NSCLC), which comprises about 80% to 85% of all lung cancers. [ 3 ] [ 4 ] [ 18 ] While there have been no randomized clinical trials of targeted agents in combined small-cell lung carcinoma (c-SCLC), [ citation needed ] some ...
There are targeted therapies for lung cancer, colorectal cancer, head and neck cancer, breast cancer, multiple myeloma, lymphoma, prostate cancer, melanoma and other cancers. [ 4 ] [ 5 ] [ 6 ] Biomarkers are usually required to aid the selection of patients who will likely respond to a given targeted therapy.
In recent years, various molecular targeted therapies have been developed for the treatment of advanced lung cancer. Gefitinib (Iressa; withdrawn from the U.S. market) is one such drug, which targets the tyrosine kinase domain of the epidermal growth factor receptor (EGFR), expressed in many cases of non-small cell lung carcinoma.
Current treatments include surgery, chemotherapy, radiation and targeted therapy for those who have a cancer with a biomarker. Doctors have good success in treating early-stage lung cancer, so ...
Lilly's drug, now called selpercatinib, is intended for patients with rare RET abnormalities, which occur in about 2% of non-small cell lung cancers, some 10 to 20% of papillary thyroid cancers ...
Cancer treatments are a wide range of treatments available for the many different types of cancer, with each cancer type needing its own specific treatment. [1] Treatments can include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy including small-molecule drugs or monoclonal antibodies, [2] and PARP inhibitors such as olaparib. [3]
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