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Linaclotide, like the endogenous guanylin and uroguanylin it mimics, is an agonist that activates the cell surface receptor of guanylate cyclase 2C (GC-C). [12] [4] [14] The medication binds to the surface of the intestinal epithelial cells. [4] Linaclotide is minimally absorbed and it is undetectable in the systemic circulation at therapeutic ...
Ironwood (IRWD) reports positive top-line data from a late-stage study evaluating Linzess (linaclotide) for functional constipation in pediatric patients aged six to 17 years.
Pleating or plaiting is a type of gathering in which the folds are usually larger, made by hand and pinned in place, rather than drawn up on threads; however, very small pleats are often identical to evenly spaced gathers.
Successful Drawing (1951). Republished in a revised edition as Three Dimensional Drawing (16 new pages with technical material on perspective replacing the pictorial gallery sections) and reissued as a full facsimile of the original on May 4, 2012, from Titan Books. Drawing the Head and Hands (1956). Reissued as a full facsimile of the original ...
Pros and cons, derived from the Latin words "pro" (for) and "contra" (against), may refer to: Pros and Cons, a television series that aired from 1991 to 1992; Pros & Cons, a 1999 film starring Larry Miller and Tommy Davidson; Pros & Cons (comic strip), a comic strip by Kieran Meehan; Decisional balance sheet, a table of pros and cons
A drawstring (draw string, draw-string) is a string, rope or lace used to "draw" (gather, or shorten) fabric or other material. Ends of a drawstring are often terminated with a sheath called an aglet. The ends may be tied to hold the drawstring in place (and simultaneously close an opening).
There are also workshops, that are like panels but are more geared towards instructions through a major or specific task such as how to draw comics, or use industry-specific software. Another event at most comic book conventions include screenings of movies and TV shows that can last through the day.
Culottes are an item of clothing worn on the lower half of the body. The term can refer to either split skirts , historical men's breeches , or women's underpants ; this is an example of fashion-industry words taken from designs across history, languages and cultures, then being used to describe different garments, often creating confusion ...