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Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate ( wintergreen oil) with an excess of sodium hydroxide .
[3] [19] [20] Aminosalicylic acid is used to induce remission in ulcerative colitis, and has been used as an antitubercular agent often administered in association with isoniazid. [21] Sodium salicylate is a useful phosphor in the vacuum ultraviolet spectral range, with nearly flat quantum efficiency for wavelengths between 10 and 100 nm. [22]
Side effects include skin irritation, and salicylate poisoning. [2] Salicylate poisoning tends to only occur when applied to a large area and in children. [2] Use is thus not recommended in children less than two years old. [2] It comes in a number of different strengths. [3] It is on the World Health Organization's List of Essential Medicines.
Methenamine/sodium salicylate, sold under the brand name Cystex among others, is a combination drug comprising methenamine and sodium salicylate.Methenamine serves as a urinary antiseptic and antibacterial agent, while sodium salicylate is a nonsteroidal anti-inflammatory drug (NSAID) and analgesic.
Plasma salicylate levels in general range from 30 to 100 mg/L after usual therapeutic doses, 50–300 mg/L in people taking high doses and 700–1400 mg/L following acute overdose. Salicylate is also produced as a result of exposure to bismuth subsalicylate, methyl salicylate, and sodium salicylate. [226] [227]
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Salsalate is a medication that belongs to the salicylate and nonsteroidal anti-inflammatory drug (NSAID) classes. Salsalate is the generic name of a prescription drug marketed under the brandnames Mono-Gesic, Salflex, Disalcid, and Salsitab. Other generic and brand name formulations may be available. [2]
Sodium salicylate is prepared by adding acetylsalicylic acid to a solution of sodium hydrogen carbonate. [citation needed] The solution is then stirred and filtered to produce sodium salicylate crystals, which are dried to remove water. [citation needed] Sodium salicylate can be synthesized into acetylsalicylate through two methods.