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A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
In humans, PDE5 inhibitors have also been shown to reduce proteinuria, a marker of kidney damage. [3] However, the successful introduction of SGLT2 inhibitors and endothelin receptor antagonists to the field of renal therapeutics makes the development of PDE5 inhibitors for this purpose unlikely.
PDE5-selective inhibitors may show good discrimination of PDE5 from most other PDE isoforms. In addition to human corpus cavernosum smooth muscle, PDE5 is also found in lower concentrations in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle .
These medications belong to a class of drugs called PDE5 inhibitors, which work by preventing the enzyme phosphodiesterase-5 from restricting blood flow to the tissue located inside your member.
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
For those in need of a tried-and-true treatment for ED, the best bet may be FDA-approved oral medications known as phosphodiesterase type 5 (PDE5) inhibitors. Similar to nitric oxide, PDE5 ...