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Gonadotropin therapy has a higher tendency to cause multiple pregnancy when compared to clomiphene and aromatase inhibitors. [11] Multiple pregnancy may increase the risks of preterm birth and decreased gestational age, which are associated with fetal complications and higher infant mortality. [11]
Letrozole and Clomiphene citrate are the first-line treatment in subfertile anovulatory patients with PCOS. [12] A Cochrane review showed that letrozole (an aromatase inhibitor) appears to improve live birth and pregnancy rates as compared to clomiphene citrate. [13] There appeared to be no difference between letrozole and laparoscopic ovarian ...
Both clomiphene and letrozole have a risk of a multiple gestation pregnancy, with the risk being less than 10%. [2] Those with hypogonadotropic hypogonadism require pulsatile GnRH therapy, which is associated with a 93-100% pregnancy rate after 6 months of therapy. [2] The risk of a multiple gestation pregnancy with gonadotropins is 36%. [2]
Triplet and higher multiple births nosedive. In 2004, of the people younger than 35 who gave birth with the help of IVF, 32.7% delivered twins, and 4.9% delivered triplets, according to doctors at ...
OHSS is characterized as cystic enlargement of the ovaries. Multiple birth is especially deleterious due to compounding risks including premature delivery and low birthweight, pre-eclampisa, and increased risk of neonatal mortality. While triplet births have been declining in ART, multiple births remain over 50% of births from IVF.
The national fertility rate — calculated as the total number of live births per 1,000 women of reproductive age — has declined steadily in the United States over the past decade, from 62.5 in ...
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women. [ 1 ] It was patented in 1986 and approved for medical use in 1996. [ 4 ]
Some foods, for example, increase inflammation, another process that affects hormonal levels. Specifically, inflammation negatively impacts Leydig cells, which are in charge of producing ...