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Modern interest in vasopressors as a treatment for cardiac arrest stem mostly from canine studies performed in the 1960s by anesthesiologists Dr. John W. Pearson and Dr. Joseph Stafford Redding in which they demonstrated improved outcomes with the use of adjunct intracardiac epinephrine injection during resuscitation attempts after induced ...
pimobendan – phosphodiesterase 3 inhibitor used to manage heart failure in dogs; pirlimycin – antimicrobial; ponazuril – anticoccidial; praziquantel – treatment of infestations of the tapeworms Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus; prazosin – sympatholytic used in hypertension and abnormal muscle contractions
Antiarrhythmic drugs should be administered after starting fluid therapy to stabilise blood pressure. Other drugs such as dobutamine should be provided if blood pressure fails to normalise, only as a last resort. Other vasopressors can be used such as ephedrine, phenylephrine, and epinephrine. [1]
An antihypotensive, also known as vasopressor, is an agent that raises blood pressure by constricting blood vessels, thereby increasing systemic vascular resistance. This is different from inotropes which increase the force of cardiac contraction. Some substances do both (e.g. dopamine, dobutamine).
More than 3,600 cases of debilitating dog health problems caused by the medication were reported between January 2023 and March 2024, the FDA said in the cautionary letter, published Monday.
Pimobendan is indicated for the management of the signs of mild, moderate, or severe congestive heart failure in dogs due to clinical myxomatous mitral valve disease (MMVD) or dilated cardiomyopathy (DCM); [1] [7] and for use with concurrent therapy for congestive heart failure (e.g.,furosemide, etc.) as appropriate on a case-by-case basis. [1]