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Furthermore, there is an increasing interest in using CBD oil to mitigate symptoms of anxiety, post-traumatic stress disorder, and depression in mild and severe forms, making it a possibly good ...
[16] [24] [26] [27] Conversion of CBD to THC can occur when CBD is heated to temperatures between 250–300 °C, potentially leading to its partial transformation into THC. [28] In the United States, the cannabidiol drug Epidiolex was approved by the Food and Drug Administration (FDA) in 2018 for the treatment of two seizure disorders. [4]
Over time, insomnia can also contribute to chronic health issues like heart disease, high blood pressure, obesity, chronic pain syndrome and diabetes. What are the causes or risk factors for insomnia?
Insomnia disorder (primary insomnia), chronic difficulty in falling asleep or maintaining sleep when no other cause is found for these symptoms. Insomnia can also be comorbid with or secondary to other disorders. Kleine–Levin syndrome, a rare disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. [84]
Biofeedback has been shown to be an effective treatment for insomnia and is listed in the American Academy of Sleep Medicine treatment guidelines. This form of therapy includes visual or auditory feedback of e.g. EEG or EMG activity. This can help insomnia patients to control their physiological arousal. [4] [38]
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[1] [2] THC and CBD are stored mostly in the trichomes of the plant, [3] and can cause psychological and physical impairment in the user, via the endocannabinoid system and unique receptors. [ 4 ] [ 5 ] THC increases dopamine levels in the brain, which attributes to the euphoric and relaxed feelings cannabis provides.
In dogs, the minimum lethal dose of THC is over 3000 mg/kg. [20] According to The Merck Index, [21] the LD 50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for male rats and 730 mg/kg for female rats from oral consumption in sesame oil, and 42 mg/kg for rats from inhalation. [22]