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A certificate of analysis (COA) is a formal laboratory-prepared document that details the results of (and sometimes the specifications and analytical methods for) one or more laboratory analyses, signed—manually or electronically—by an authorized representative of the entity conducting the analyses. This document gives assurances to the ...
3,5,7-Trioxododecanoyl-CoA synthase (EC 2.3.1.206, TKS) is an enzyme with systematic name malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming). [1] [2] This enzyme catalyses the following chemical reaction
Prydz K, Kase BF, Björkhem I, Pedersen JI (August 1988). "Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver". Journal of Lipid Research. 29 (8): 997– 1004. PMID 3183523
The acyl-CoA breaks at the thioester bond, forming a CoA and carboxylic acid. The carboxylic acid remains bound to the enzyme, but it is soon displaced by CoA and leaves. A new carboxylic acid (the CoA acceptor) enters and forms a new acyl-CoA. The new acyl-CoA is released, completing the transfer of CoA from one molecule to another.
The sole carbon feed stock of the pathway is acetyl-CoA. The first step condenses two acetyl-CoA molecules to yield acetoacetyl-CoA. This is followed by a second condensation to form HMG-CoA (3-hydroxy-3- methyl-glutaryl-CoA). Reduction of HMG-CoA yields (R)-mevalonate. These first 3 enzymatic steps are called the upper mevalonate pathway. [4]
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A W-2 form is a crucial document you need when ... you can file a Form W-2 complaint. Call the IRS toll-free at 800-829-1040 or make an appointment to visit an IRS Taxpayer Assistance Center ...
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