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  2. Lubiprostone - Wikipedia

    en.wikipedia.org/wiki/Lubiprostone

    Lubiprostone, sold under the brand name Amitiza among others, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. The drug is owned by Mallinckrodt and is marketed by Takeda Pharmaceutical Company.

  3. Naloxegol - Wikipedia

    en.wikipedia.org/wiki/Naloxegol

    Naloxegol (INN; PEGylated naloxol; [4] trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation. [5] It was approved in 2014 in adult patients with chronic, non-cancer pain. [6]

  4. Functional gastrointestinal disorder - Wikipedia

    en.wikipedia.org/wiki/Functional...

    C2. Functional constipation; C3. Functional diarrhea; C4. Functional abdominal bloating/distension; C5. Unspecified functional bowel disorder; C6. Opioid-induced constipation; D. Centrally mediated disorders of gastrointestinal pain. D1. Centrally mediated abdominal pain syndrome (CAPS) D2. Narcotic bowel syndrome (NBS)/ Opioid-induced GI ...

  5. Results from Phase III Studies of Naloxegol for Treatment of ...

    www.aol.com/2013/05/21/results-from-phase-iii...

    Results from Phase III Studies of Naloxegol for Treatment of Opioid-Induced Constipation Presented at Digestive Disease Week 2013 ORLANDO, Fla.--(BUSINESS WIRE)-- AstraZeneca (NYS: AZN) today ...

  6. Opioid addicts using anti-diarrhea medication to get high ...

    www.aol.com/news/2016-05-06-opioid-addicts-using...

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  7. Opioid - Wikipedia

    en.wikipedia.org/wiki/Opioid

    Partial agonists, like the anti-diarrhea drug loperamide and antagonists, like naloxegol for opioid-induced constipation, do not cross the blood–brain barrier, but can displace other opioids from binding to those receptors in the myenteric plexus. Because opioids are addictive and may result in fatal overdose, most are controlled substances.

  8. Methylnaltrexone - Wikipedia

    en.wikipedia.org/wiki/Methylnaltrexone

    Methylnaltrexone (MNTX, brand name Relistor), used in form of methylnaltrexone bromide (INN, USAN, BAN), is a medication that acts as a peripherally acting μ-opioid receptor antagonist that acts to reverse some of the side effects of opioid drugs such as constipation without significantly affecting pain relief or precipitating withdrawals.

  9. Peripherally acting μ-opioid receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Peripherally_acting_μ...

    Opioid drugs are known to cause opioid-induced constipation (OIC) by inhibiting gastric emptying and decreasing peristaltic waves leading to delayed absorption of medications and more water absorption from the feces. That can result in hard and dry stool and constipation for some patients. [2]