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However, ulcerative colitis usually affects the rectum and inflammation in IBD extends to areas of the colon without diverticulosis. [1] Additional causes of colitis should be evaluated, including infectious and medication-induced, particularly NSAID-associated. [1] Laboratory results are usually normal in individuals with SCAD.
Segmental colitis associated with diverticulosis (SCAD) is a condition characterized by localized inflammation of the colon between diverticula (interdiverticular mucosa) while sparing the diverticular orifices. SCAD may lead to abdominal pain, especially in the left lower quadrant, intermittent rectal bleeding, and chronic diarrhea.
These patients may even have blood on their rectal exam, due to passing small amounts of stool around the ulcer and adjacent fecaloma. [2] Patients may have unstable vital signs if they have been having rectal bleeding, have developed stercoral colitis, and/or have had a perforation of the ulcer.
Complicated acute diverticulitis is distinguished from uncomplicated diverticulitis by the presence of abscess or colonic perforation. Chronic smoldering diverticulitis is caused by recurrent acute diverticulitis that does not respond to medical treatment but does not progress to complications such as abscess, peritonitis, enteric fistula, or ...
Uncomplicated acute diverticulitis is defined as localized diverticular inflammation without any abscess or perforation. [46] Complicated diverticulitis additionally includes the presence of abscess, peritonitis, obstruction, stricture and/or fistula. 12% of patients with diverticulitis present with complicated disease. [47]
Toxic megacolon is mainly seen in ulcerative colitis and pseudomembranous colitis, two chronic inflammations of the colon (and occasionally, in the other type of inflammatory bowel disease, Crohn's disease). Its mechanism is incompletely understood. It is probably due to excessive production of nitric oxide, at least in ulcerative colitis. The ...
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